hCD4

Background : C57BL/6Smoc

Catalog : NM-HU-00115

Strain Name :

C57BL/6Smoc-Cd4em1(hCD4) Smoc

Gene Summary

Gene Name

Model Description

The endogenous mouse Cd4 gene was replaced by human CD4 gene .

Validation Data

CD4-hu-1.png

CD4-hu-2.png

Fig 1. Flow cytometric analysis of the T cell subtype proportions in peripheral blood from control and the humanized CD4 mouse model. 

 A Lymphocyte dot plots. The gate for lymphocytes is indicated.   B Statistical analyses of the CD8+ T cell and CD4+ T cell  in the indicated groups. *P<0.05,**P<0.01.

CD4-hu-3.png

CD4-hu-4.png

Fig2. Flow cytometric analysis of the T cell subtype proportions in thymus from control and the humanized CD4 mouse model. A Lymphocyte dot plots. The gate for lymphocytes is indicated.   B Statistical analyses of the CD8+ T cell and CD4+ T cell  in the indicated groups. *P<0.05.

image.png

Fig3. Expression characterization of hCD4 in hCD4 KI mice.

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