Dies1, PD-1H, VISTA, 4632428N05Rik
胚胎冻存
Figure 1. Detection of VISTA expression in peripheral blood cells of humanized VISTA mice.
The expression of human VISTA was detected by FACS. The results showed that the active expression of human VISTA can be detected in both activated CD4+ and CD8+ T lymphocytes collected from humanized VISTA mice.
Figure 2. In vivo validation of anti-tumor efficacy in a MC38 tumor-bearing model of humanized VISTA mice.
Humanized VISTA mice were inoculated with MC38 colon cancer cells,the animals were randomly assigned into a control group and a treatment group (n=6). The drug was administered on days 0, 3, 7, 10, 14, and 17 respectively.The antibody showed significant tumor inhibition at the recommended dose(TGI: tumor growth inhibition, p < 0.01). (Cooperation with WuXi Biologics)
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