hICOS/hICOSL

Background : C57BL/6Smoc

Catalog : NM-HU-18018

Strain Name :

C57BL/6Smoc-Icoslem1(hICOSLG) Icosem1(hICOS)/Smoc

Gene Summary

Gene Name

Model Description

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Validation Data

image.png

Fig1. Detection of hICOSL expression on activated APCs in hICOSL KI mice and hICOS/hICOSL dKI mice. 

Note. The splenocyte-derived activated APCs were stimulated by LPS in vitro.

image.png

Fig2. Detection of hICOS expression on splenocyte-derived activated T cells in hICOS/hICOSL dKI mice.



Related Strains

Product
Product Catalog
Background
NM-NSG-007
NOD
Inquire
NM-NSG-017
huHSC
Inquire
NM-KI-200229
C57BL/6Smoc
Inquire
NM-KI-200255
C57BL/6Smoc
Inquire
NM-KI-200020
C57BL/6Smoc
Inquire
NM-HU-230344
C57BL/6Smoc
Inquire
NM-KI-190114
C57BL/6Smoc
Inquire
NM-HU-210037
C57BL/6Smoc
Inquire
NM-HU-225042
C57BL/6Smoc
Inquire
NM-HU-2000072
C57BL/6Smoc
Inquire
Email Back to top