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Notch1-CreERT2

Background : C57BL/6Smoc

Catalog : NM-KI-200122

Strain Name : C57BL/6Smoc-Notch1^{em1(CreERT2-2xpA)Smoc}

Gene Summary

Gene Name

Synonyms :
N1, Mis6, Tan1, lin-12, 9930111A19Rik
NCBI ID :
18128
MGI ID :
97363
Ensembl ID :
ENSMUSG00000026923
Strain State :
胚胎冻存

Model Description

A CreERT2-2xpA expression cassette was knocked into the Notch1 gene start codon site. Notch1 performs vital cell functions, such as proliferation, differentiation, apoptosis, and stem cell maintenance. When Notch1-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in NOTCH1 positive cells.

Validation Data

Fig. 1 CreERT2-mediated recombination in individual cells of small intestinal derived from Notch1-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

Fig. 2 CreERT2-mediated recombination in individual cells of liver derived from Notch1-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

Fig. 3 Labeling was also observed in individual cells of the brain, heart, brown fat, salivary gland, lung, liver, stomach, kidney, pancreas, epidermis, colon, spleen, thymus and muscle.(For more information please contact: 400-728-0660.)

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