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Nkx2-1-CreERT2

Background : C57BL/6Smoc

Catalog : NM-KI-200123

Strain Name : C57BL/6Smoc-Nkx2-1^{em1(CreERT2-pA)Smoc}

Gene Summary

Gene Name

Synonyms :
T/EBP, Titf1, Ttf-1, Nkx2.1, AV026640
NCBI ID :
21869
MGI ID :
108067
Ensembl ID :
ENSMUSG00000001496
Strain State :
活体

Model Description

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.

Validation Data

Nkx2-1-(CreERT2)-1.png

Fig. 1 Detection of tdTomato (red) in the pulmonary epithelial cells of Nkx2-1CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. CreERT2-mediated recombination in some of the bronchial and alveolar epithelial cells of Nkx2-1CreERT2/+; Rosa26tdTomato/+ mouse can be induced by tamoxifen.

Nkx2-1-(CreERT2)-2.png

Fig. 2 Detection of tdTomato (red) in various tissues of Nkx2-1CreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. CreERT2-mediated recombination in the lung can be induced by tamoxifen. And tdTomato expression can not be observed in the pituitary gland, retina, heart, liver, stomach, colon, intestine, kidney, pancreas, etc.

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