Wt1-CreERT2

Fig. 1 CreERT2-mediated recombination in the heart of Wt1^CreERT2/+; Rosa26^tdTomato/+ mouse. 

Detection of tdTomato (red) in the epicardium of Wt1^CreERT2/+; Rosa26^tdTomato/+ mouse after tamoxifen treatment.

Fig. 2 CreERT2-mediated recombination in the heart of Wt1^CreERT2/+; Rosa26^tdTomato/+ mouse embryo at E10.5. 

Detection of tdTomato (red) in the heart of Wt1^CreERT2/+; Rosa26^tdTomato/+ mouse embryo at E10.5 after tamoxifen treatment.

Fig. 3 CreERT2-mediated recombination in the liver of Wt1^CreERT2/+; Rosa26^tdTomato/+ mouse. 

Detection of tdTomato (red) in the mesothelial cell of the liver derived from Wt1^CreERT2/+; Rosa26^tdTomato/+ mouse after tamoxifen treatment.

Fig. 4 CreERT2-mediated recombination in the testis of Wt1^CreERT2/+; Rosa26^tdTomato/+ mouse. 

Detection of tdTomato (red) in the tunica albuginea, tunica vaginalis and individual cells of parenchymal structure of the testis derived from Wt1^CreERT2/+; Rosa26^tdTomato/+ mouse after tamoxifen treatment.

Fig. 5: Detection of tdTomato(red) in various tissues of Wt1^CreERT2/+; Rosa26^tdTomato/+ mice. CreERT2 mediated recombination can be detected in the tunica externa of heart, liver, spleen, stomach, intestine, colon after tamoxifen treatment. Some leakiness were detected in the spleen prior to tamoxifen exposure. Besides, tdtomato expression can be detected in a few cells of the pancreas and thymus. Tdtomato expression can not be observed in the brain, pituitary gland, retina, lung, submandibular gland, skin and muscle. (For more detailed information please contact our technical advisor.)