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Home / Toolbox of Mice / Find Cre / Il13-IRES-Cre

Il13-IRES-Cre

Background : C57BL/6Smoc

Catalog : NM-KI-200166

Strain Name : C57BL/6Smoc-Il13em1(IRES-iCre)Smoc

Gene Summary

Gene Name

Model Description

A IRES-iCre expression cassette was knocked into the Il13 gene stop codon site. This gene encodes a multifunctional cytokine. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This cytokine participates in the regulation of immune response, inflammatory response and hematopoietic process.

Validation Data

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Fig. 1 Cre-mediated recombination in the thymus of Il13Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in  individual cells of the thymus derived from Il13Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the spleen of Il13Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in  the spleen derived from Il13Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of  Il13Cre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination can be detected in some cells of the thymus and spleen and in individual cells of the stomach and testis. Tdtomato expression can not be observed in the heart. (For more detailed information please contact our technical advisor.)


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