Krt5-IRES-CreERT2

Background : C57BL/6Smoc

Catalog : NM-KI-200168

Strain Name : C57BL/6Smoc-Krt5em1(IRES-CreERT2)Smoc

Gene Summary

Gene Name
  • Synonyms :

    K5, CK5, Tfip8, Krt2-5, AW146334, 3300001P10Rik

  • NCBI ID :

    110308

  • MGI ID :

    96702

  • Ensembl ID :

    ENSMUSG00000061527

  • Strain State :

    活体

Model Description

A IRES-CreERT2 expression cassette was knocked into the Krt5 gene stop codon site.

Validation Data

Krt5-IRES-CreERT2-1 - 副本.png

Fig. 1 Detection of tdTomato (red) in the epidermis and hair follicle of Krt5CreERT2/+; Rosa26tdTomato/+  mouse. CreERT2-mediated recombination in the epidermis and hair follicle of Krt5CreERT2/+; Rosa26tdTomato/+ mouse. Some leakiness were detected in the epidermis and hair follicle prior to tamoxifen exposure.

Krt5-IRES-CreERT2-2 - 副本.png

Fig. 2 Detection of tdTomato (red) in various tissues of Krt5CreERT2/+; Rosa26tdTomato/+ mice. 

CreERT2-mediated recombination in the brown fat and submandibular gland can be induced by tamoxifen. Some leakiness were detected in the skin,eyes and testis prior to tamoxifen exposure.

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