Pbsn-2A-CreERT2

Background : C57BL/6Smoc

Catalog : NM-KI-200190

Strain Name :

C57BL/6Smoc-Pbsnem1(V5-2A-CreERT2-WPRE-polyA)Smoc

Gene Summary

Gene Name

Model Description

A V5-2A-CreERT2-WPRE-polyA expression cassette was knocked into the Pbsn gene stop codon site.

Validation Data

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Fig1. Expression Pattern of Tomato in PbsnCreERT2/+;Rosa26tdTomato/+ mice.

CreERT2-mediated recombination in prostate epithelial cells of PbsnCreERT2/+ ; Rosa26tdTomato/+ mice. This strain represents an effective tool for generating prostate specific-targeted mutants.

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Fig2. Cre mediated recombination in prostate of PbsnCreERT2/+;Rosa26tdTomato/+ mouse. 

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Fig3. Detection of tdTomato(red) in various tissues of PbsnCreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: prostate, salivary gland. A few cells expressed in adrenal gland, pancreas, testis, muscle and thymus. Tissues that unexpressed include brain, spinal cord, eyeball, heart, lung, liver, stomach, brown fat, kidney, colon, small intestine, spleen, and skin. (9-week old, male) (For more detailed information please contact our technical advisor.)

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