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hOX40/hOX40L(2)

Background : C57BL/6Smoc

Catalog : NM-HU-200263

Strain Name : C57BL/6Smoc-Tnfrsf4^{em1(hTNFRSF4)}Tnfsf4^{em2(hTNFSF4)/Smoc}

Gene Summary

Gene Name

Synonyms :
Ath1, gp34, Ath-1, Ox40l, TXGP1, CD134L, OX-40L, Tnlg2b, Txgp1l, Ox40, ACT35, CD134, Ly-70, Txgp1, TXGP1L
NCBI ID :
22164 22163
MGI ID :
104511 104512
Ensembl ID :
ENSMUSG00000026700 ENSMUSG00000029075
Strain State :
Embryo cryopreservation

Model Description

hTNFSF4（NM-HU-200005）was crossed with hOX40（NM-HU-00041）to generate hOX40/hOX40L(2) mice

Validation Data

Fig1. OX40 expression on CD4+ T cells in spleen in hOX40 KI mice.

Fig2. OX40 expression on Treg cells in spleen in hOX40 KI mice.

Fig3. Detection of hOX40L expression on stimulated APCs in hOX40/hOX40L dKI mice.

Fig4. OX40 antibody showed dose-dependent anti-tumor activity in human OX40 knock-in mice bearing MC38 tumors.(The OX40 antibody was obtained from Innoventbio)

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