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hPD-1/hCTLA-4(BALB/c)

Background : BALB/cAnSmoc

Catalog : NM-HU-200277

Strain Name :

BALB/cAnSmoc-Pdcd1^em1(hPDCD1)Ctla4^{em1(hCTLA4)Smoc}

Gene Summary

Gene Name

Synonyms :
PD-1, Pdc1, Ly101, Cd152, Ly-56, Ctla-4
NCBI ID :
18566 12477
MGI ID :
104879 88556
Ensembl ID :
ENSMUSG00000026285 ENSMUSG00000026011
Strain State :
Embryo cryopreservation

Model Description

hPD-1(NM-HU-190079) was crossed with hCTLA4(2)(NM-HU-190078)to generate hPD-1/hCTLA4 mice

Validation Data

Fig 1.In vivo efficacy study in PD1 & CTLA4 humanized mice. Keytruda, Opdico or Yervoy can inhibit the growth of CT26-hCD274 xenografts. The above data indicated that the hPD1/hCTLA4 humanized mouse is an effective model for antineoplastic drug screening.

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