hEPCAM - Genobiotx

Gene Summary

Gene Name

Synonyms :
EGP, Ly74, gp40, CD326, EGP-2, TROP1, Egp314, Ep-CAM, EpCAM1, Tacsd1, GA733-2, Tacstd1
NCBI ID :
17075
MGI ID :
106653
Ensembl ID :
ENSMUSG00000045394
Strain State :
精子冻存

Model Description

The endogenous mice Epcam gene was completely or partially replaced by human EPCAM gene via ESC targeting.

Validation Data

Fig1. Analysis of mouse EPCAM and human EPCAM protein expression in the large intestine by IHC. Both the EPCAM humanized heterozygous mouse and wild type express mouse EPCAM in the mucosal epithelial membranes, and the humanized heterozygous mouse expresses human EPCAM in the crypts significantly.

Fig2. Analysis of mouse EPCAM and human EPCAM protein expression in the small intestine by IHC. Both the EPCAM humanized heterozygous mouse and wild type express mouse EPCAM in the mucosal epithelial membranes, and the humanized heterozygous mouse expresses human EPCAM in the crypts significantly.

Fig3. Detection of human EpCAM expression in WT C57 and homozygous hEpCAM mice by IHC. Small intestine were collected from wild-type mice (+/+) and homozygous hEpCAM mice (HO/HO), and analyzed by IHC with anti-human EpCAM antibody.

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