Ccr2-IRES-DTRGFP

Background : C57BL/6Smoc

Catalog : NM-KI-210102

Strain Name : C57BL/6Smoc-Ccr2em1(IRES-DTRGFP)Smoc

Gene Summary

Gene Name
  • Synonyms :

    Ckr2, Ccr2a, Ccr2b, Ckr2a, Ckr2b, mJe-r, Cmkbr2, Cc-ckr-2

  • NCBI ID :

    12772

  • MGI ID :

    106185

  • Ensembl ID :

    ENSMUSG00000049103

  • Strain State :

    活体

Model Description

IRES-DTRGFP expression cassette was knocked into the Ccr2 gene .

Validation Data

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Fig1. Analysis of GFP expression in the Ccr2-IRES-DTRGFP mice by FACS. The expression of GFP could be detected in CCR2+ and CD11b+ cells in peripheral blood of the heterozygous KI mice.

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Fig2. Analysis of CCR2+/CD11b+ cells proportion and GFP level in Ccr2-IRES-DTRGFP mice by FACS. The heterozygous KI mice were treated with DT (qd x 3 days).After 2 days of drug withdrawal, the proportion of CCR2+ and CD11b+ cells in the peripheral blood were decreased, and the level of GFP positive cells also decreased. After 4 days of drug withdrawal, the proportion of CCR2+ and CD11b+ cells returned to normal, and the level of GFP positive cells also returned to normal.

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