Cre-lox system, characterized by simple manipulation and high-efficiency recombinase, has been employed as a powerful tool of gene-editing. Application of Cre-lox system can achieve time-specific knock-out and knock-in of target genes in specified cells, tissues, and organisms, thereby regulating genes of interest spatiotemporally, which has profound impact on research of genetic function and animal modeling. […]
You may have come across accumulating reports uncovering biomedical breakthroughs which all use humanized mice in vivo assays. So, you may wonder, what is a humanized mouse and why is it so commonly used in biomedical research? Humanized mouse is generally referred to as a mouse has been xenotransplanted with human cells and/or engineered to express human gene products, so as to be applied to […]
Now that the genetically engineered mice that carry a Cre-conditional (“floxed”) allele in target gene are at your hand. And the mice are supposed to express Cre in target tissue. The validation of your Cre-lox model become very indispensable, so here we advise you of some essential steps. Genotype the mice When unexpected phenotypes are observed during your working with mice, the […]
Aclidineleukin (high-dose IL-2) is the first FDA-approved cancer immunotherapy for metastatic renal cell carcinoma (RCC) and melanoma, but the widespread clinical use of aclidinein has been limited by its short half-life, serious side effects, and simultaneous stimulation of Treg activation. With the breakthrough of studies of immune checkpoint inhibitors, IL-2-based therapeutics has regained widespread attention, […]
CCR8, as a novel immune checkpoint in tumor microenvironment, was hotly discussed during 2022 AACR conference. Since then, numerous prestigious pharmaceutical corporations have shifted their attention to CCR8, previously almost unknown. You may wonder why CCR8 gave rise to so strong interest of pharmaceutical industry. Just follow us to have a quick review of CCR8, […]
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