Knock-Out

Gene knockout mouse models are beneficial for insight into key genetic mechanisms, accelerating your research. Discover gene functions, understand disease pathogenesis, and advance drug development processes.

Conventional knockout
Conditional knockout

Knock-Out applications

Discover gene functions, explore cellular processes.
Gain a deep understanding of disease mechanisms and prevention methods.
Simplify the efficacy evaluation in drug discovery.

Using ES cell targeting technology

Characteristics of ES cell targeting technology

Long cycle: 7-12 months
Mature technology, precise with no off-target effects.
Capable of various complex genetic modifications

Conventional Knock-Out

Osteoporosis mice model

Osteoprotegerin (OPG) gene polymorphism is associated with bone density

The OPG knockout mouse model established using gene knockout technology exhibits clear symptoms of osteoporosis.

It provides an ideal animal model for the study of human osteoporosis.

Parkinson's disease mouse model

Mutations in the SLC39A14 gene lead to manganese accumulation in the brain and early-onset Parkinson-like pathology.

Slc39a14 knockout mice exhibit significant manganese accumulation and behavioral abnormalities.

By crossing Slc39a14-flox mice with Alb-Cre mice, liver-specific Slc39a14 knockout mice were obtained, and it was found that the loss of Slc39a14 in the liver was not sufficient to cause manganese accumulation.

Knock-Out

Knock-Out applications

Using CRISPR gene editing technology

Using ES cell targeting technology

Conventional Knock-Out

Osteoporosis mice model

Conditional Knock-Out

Using CRISPR gene editing technology

Using CRISPR gene editing technology

Parkinson's disease mouse model