You may have come across accumulating reports uncovering biomedical breakthroughs which all use humanized mice in vivo assays. So, you may wonder, what is a humanized mouse and why is it so commonly used in biomedical research? Humanized mouse is generally referred to as a mouse has been xenotransplanted with human cells and/or engineered to express human gene products, so as to be applied to […]
Cre-lox system, characterized by simple manipulation and high-efficiency recombinase, has been employed as a powerful tool of gene-editing. Application of Cre-lox system can achieve time-specific knock-out and knock-in of target genes in specified cells, tissues, and organisms, thereby regulating genes of interest spatiotemporally, which has profound impact on research of genetic function and animal modeling. […]
Now that the genetically engineered mice that carry a Cre-conditional (“floxed”) allele in target gene are at your hand. And the mice are supposed to express Cre in target tissue. The validation of your Cre-lox model become very indispensable, so here we advise you of some essential steps. Genotype the mice When unexpected phenotypes are observed during your working with mice, the […]
The 2024 Nobel Prize in Physiology or Medicine has been announced, and the winners are two American scientists, Victor Ambros and Gary Ruvkun, in recognition of their discovery of microRNA and its role in post-transcriptional gene regulation. This discovery is considered a major breakthrough following the central dogma of molecular biology. The Nobel Committee stated […]
Registration link: https://www.eventbrite.com/e/genobiotx-monthly-webinar-tickets-1053785844829 Date: Wednesday, Oct 30th, 2024; 11:00 am PDT, or 2:00 pm EDT Webinar Highlights: This seminar will introduce GenoBioTX’s gene editing platform and technology, highlighting how these techniques can enhance your research projects. We will cover the history of genome editing, provide an overview of GenoBioTX’s gene editing platform and technology, and present […]
Aclidineleukin (high-dose IL-2) is the first FDA-approved cancer immunotherapy for metastatic renal cell carcinoma (RCC) and melanoma, but the widespread clinical use of aclidinein has been limited by its short half-life, serious side effects, and simultaneous stimulation of Treg activation. With the breakthrough of studies of immune checkpoint inhibitors, IL-2-based therapeutics has regained widespread attention, […]
CCR8, as a novel immune checkpoint in tumor microenvironment, was hotly discussed during 2022 AACR conference. Since then, numerous prestigious pharmaceutical corporations have shifted their attention to CCR8, previously almost unknown. You may wonder why CCR8 gave rise to so strong interest of pharmaceutical industry. Just follow us to have a quick review of CCR8, […]
Join our webinar on June 26th to explore the development and preclinical evaluation of Antibody-Drug Conjugates (ADCs), focusing on their components, mechanisms, and the selection of effective preclinical models for advancing targeted cancer therapies. Date: · Wednesday, June 26th, 2024; 2:00 pm EDT or 11:00 am PDT Webinar Highlights: Meet Our Speaker: Dr. Hua Wei […]
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