4T1-hCD47

Background : 4T1

Catalog : NM-S07-TM02

Strain Name :

4T1-Cd47em1(hCD47)Smoc

Gene Summary

Gene Name

Model Description

The endogenous mouse Cd47 gene was replaced by human CD47 gene.

Validation Data

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Fig1. hCD47 expression on in vitro cultured cells of 4T1-hCD47. (In collaboration with CrownBio)

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Fig2. In vivo validation of 4T1-hCD47 in hSIRPA/hCD47 (BALB/c) mice. (In collaboration with CrownBio) hSIRPA/hCD47 Balb/C mice were inoculated subcutaneously with 4T1 at 3×105 and 4T1-hCD47 at 3×106 cells/mouse inoculum for tumor development.

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Fig3. hCD47 expression in tumors after in vivo growth of 4T1-hCD47 in hSIRPA/hCD47(BALB/c) mice. (In collaboration with CrownBio) The tumors were collected at day 35 and day 40 post tumor cell inoculation.

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