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Home / Abcb4-KO(FVB)

Abcb4-KO(FVB)

Background : FVB

Catalog : NM-KO-200584

Strain Name :

FVB-Abcb4em1Smoc

Gene Summary

Gene Name

Model Description

Exon 3-4 of Abcb4 gene was deleted to generate Abcb4 knockout mice.

Validation Data

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Fig1. Serum biochemistry of Abcb4-KO mice (n=3 female and 3 male).

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Fig2. Significant bile duct hyperplasia and interstitial focal cell infiltration were observed in the liver of Abcb4-KO mice.

(A) Liver were collected from FVB wild-type (+/+) and Abcb4-KO mice, and analyzed by HE staining. (B) Pathological analysis of the liver in Abcb4-KO mice.

image.png

Fig3. Collagen fiber hyperplasia were observed in the liver of Abcb4-KO mice.

(A) Liver were collected from FVB wild-type (+/+) and Abcb4-KO mice, and analyzed by Masson staining. (B) Quantification of the Collagen volume fraction (CVF) .

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