Anxa10-2A-CreERT2

Background : C57BL/6Smoc

Catalog : NM-KI-200312

Strain Name : C57BL/6Smoc-Anxa10em1(2A-CreERT2-Wpre-pA)Smoc

Gene Summary

Gene Name

Model Description

2A-CreERT2-Wpre-pA expression cassette was knocked into the Anxa10 gene stop codon site.

Validation Data

Anxa10-2A-CreERT2-1.png

Fig.1 CreERT2-mediated recombination in the stomach of Anxa10CreERT2/+ ; Rosa26tdTomato/+ mouse. 

TdTomato(red) expression can be detected in the gastric mucosal epithelial cell of Anxa10CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

Anxa10-2A-CreERT2-2.png

Fig.2 Detection of tdTomato (red) in various tissues of Anxa10CreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. 

CreERT2-mediated recombination in the gastric mucosal cells and hair follicle cells can be induced by tamoxifen. A small degree of leakiness were detected in the thymus prior to tamoxifen exposure. Besides, tdtomato expression can not be detected in the brain, eyes, heart, lung, liver, submandibular gland, kidney, ovary, uterus, intestine, colon, spleen, brown fat, and muscle. (For more detailed information please contact our technical advisor.)

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