Strain Model Specification

Anxa10-2A-CreERT2

Strain Name C57BL/6Smoc-Anxa10em1(2A-CreERT2-Wpre-pA)Smoc
Catalog Number NM-KI-200312
Genetic Background C57BL/6Smoc
Gene Symbol Anxa10
NCBI ID 26359 ↗
MGI ID 1347090 ↗
Ensembl ID ENSMUSG00000031635 ↗
Strain State Sperm cryopreservation
Research Application These mice express tamoxifen induced cre recombinase from the Anxa10 locus. By mating the reporter mice with CreERT2-expressing mice, reporter gene expression can be detected in gastric mucosa epithelial cells after tamoxifen treatment. And the mice are useful for generating conditional mutations in gastric mucosa epithelial cells. This strain may useful for in the research of gastric carcinoma.

Validation Data

Anxa10-2A-CreERT2-1.png

Fig.1 CreERT2-mediated recombination in the stomach of Anxa10CreERT2/+ ; Rosa26tdTomato/+ mouse. 

TdTomato(red) expression can be detected in the gastric mucosal epithelial cell of Anxa10CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

Anxa10-2A-CreERT2-2.png

Fig.2 Detection of tdTomato (red) in various tissues of Anxa10CreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. 

CreERT2-mediated recombination in the gastric mucosal cells and hair follicle cells can be induced by tamoxifen. A small degree of leakiness were detected in the thymus prior to tamoxifen exposure. Besides, tdtomato expression can not be detected in the brain, eyes, heart, lung, liver, submandibular gland, kidney, ovary, uterus, intestine, colon, spleen, brown fat, and muscle. (For more detailed information please contact our technical advisor.)