Strain Model Specification

Aqp5-Cre

Strain Name C57BL/6Smoc-Aqp5em1(iCre-WPRE-polyA)Smoc
Catalog Number NM-KI-200062
Genetic Background C57BL/6Smoc
Gene Symbol Aqp5
NCBI ID 11830 ↗
MGI ID 106215 ↗
Ensembl ID ENSMUSG00000044217 ↗
Strain State Sperm cryopreservation
Research Application Cre recombinase tool; Aquaporin 5 (AQP5) belongs to a family of water channel proteins that allow water to pass through the plasma membrane by osmosis. AQP5 is expressed in salivary gland and lung epithelial cells. When crossed with a reporter mice, reporter gene expression can be detected in Aqp5 positive cells. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.

Validation Data

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Fig. 1 Cre-mediated recombination in the lung of Aqp5Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the lung epithelial cells derived from Aqp5Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of Aqp5Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in lung epithelial cells, salivary gland, pancreas, brain, stomach, large intestine and esophagus. TdTomato can also be detected in individual cells of the heart, kidney, spleen, ovary and uterus. (For more detailed information please contact our technical advisor.)