Strain Model Specification

Ccr2-KO

Strain Name C57BL/6Smoc-Ccr2em1Smoc
Catalog Number NM-KO-190018
Genetic Background C57BL/6Smoc
Gene Symbol Ccr2
Synonyms CC-CKR-2, CCR2A, CCR2B, CKR2, CKR2A, CKR2B, Cmkbr2
NCBI ID 12772 ↗
MGI ID 106185 ↗
Ensembl ID ENSMUSG00000049103 ↗
Strain State Repository Live
Research Application Immune-related

Validation Data

image.png

Fig1. Validation of Ccr2 gene expression by RT-PCR.(A) Schematic diagram of primer design; (B) No product was obtained from Ccr2 knockout homozygous mice, and the wild-type mice could obtain the 824bp target PCR product. (M, DNA marker; HO, homozygous; WT, wild type)


image.png

Fig2. Validation of  CCR2 expression in the bone marrow by FACS. CCR2 expression could not be detected on CD11b+ cells of the Ccr2 knockout homozygous mice. 


image.png

Fig3. Validation of CCR2 expression in the spleen by FACS. CCR2 expression could not be detected on CD11b+ cells of the Ccr2 knockout homozygous mice.