Strain Model Specification

Cdk4-KO

Strain Name C57BL/6Smoc-Cdk4em1Smoc
Catalog Number NM-KO-190614
Genetic Background C57BL/6Smoc
Gene Symbol Cdk4
Synonyms Crk3
NCBI ID 12567 ↗
MGI ID 88357 ↗
Ensembl ID ENSMUSG00000006728 ↗
Strain State Developing
Research Application The protein encoded by this gene is a member of the Ser/Thr protein kinase family.It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb).