Col4a5-R471X - GenoBioTX

Gene Summary

Gene Name

NCBI ID :
12830
MGI ID :
88456
Ensembl ID :
ENSMUSG00000031274
Strain State :
Repository Live

Model Description

These mice carry a R471X mutation of Col4a5 gene.

Validation Data

Fig1. Col4a5 mRNA level was measured in Col4a5-R471X mice (n=3, male, 6 week-old) and the point mutation of Col4a5 has been verified by sequencing.

Abbr. HO, homozygous; WT, wild type.

Fig2. The results of urine (A) and blood (B) biochemical indicators in Col4a5-R471X mice (n=2 male and 6 female).

Abbr. WT, wild type.

Fig3. The results of urine (A) and plasma (B) biochemical indicators in 21-weeks-old Col4a5-R471X mice (n=3/group).(Data from a cooperator)

Abbr. WT, wild type.

Fig 4. Effects of Ramipril (10mg/kg) on urine (A) and blood (B) biochemical indicators of Col4a5-R471X mice over a 16-17 weeks treatment period (6 weeks of age at initiation time, n=4-5 male and 4-5 female in each group).

Abbr. WT, wild type.

Fig 5. Effects of Ramipril (10mg/kg) on urine (A) and plasma (B) biochemical indicators of male and female Col4a5-R471X mice over a 16-17 weeks treatment period respectively (6 weeks of age at initiation time, n=4-5 male and 4-5 female in each group).

Abbr. WT, wild type.