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hAppNL-G-F

Background : C57BL/6Smoc

Catalog : NM-HU-2000088

Strain Name : C57BL/6Smoc-App^{tm3(hAppNL-G-F)/Smoc}

Gene Summary

Gene Name

Synonyms :
Ag, Abpp, Adap, Cvap, Abeta, betaApp, E030013M08Rik
NCBI ID :
11820
MGI ID :
88059
Ensembl ID :
ENSMUSG00000022892
Strain State :
活体

Model Description

The endogenous mouse App gene was replaced by human AppNL-G-F.

Validation Data

Fig1. Detection of APP expression in brain by RT-PCR.

Fig2. (A) β-Amyloid (6E10) staining of WT and hAPPNL-G-F mice at 1, 3 and 6 months (magnification, 40x and 100x). (B) Statistics of 6E10 positive plaque area.

Fig3. (A) Thioflavine S staining of WT and hAPPNL-G-F mice at 1, 3 and 6 months (magnification, 40x and 100x). (B) Statistics of ThiS positive plaque area.

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