Strain Model Specification

hCD3E

Strain Name C57BL/6Smoc-Cd3etm1(hCD3E) Smoc
Catalog Number NM-HU-00114
Genetic Background C57BL/6Smoc
Gene Symbol Cd3e
Synonyms CD3, T3e, AI504783, CD3epsilon
NCBI ID 12501 ↗
MGI ID 88332 ↗
Ensembl ID ENSMUSG00000032093 ↗
Strain State Repository Live
Research Application Immunotherapy,cancer research,drug screening

Validation Data

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Fig1. The expression of human CD3E in the peripheral blood cells derived from heterozygous or homozygous humanized mice was confirmed by FACS. 

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Fig2. Detection of T cell subsets in the peripheral blood cells derived from heterozygous or homozygous CD3E humanized mice.

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Fig3. Detection of B and NK cells in the peripheral blood cells derived from heterozygous or homozygous CD3E humanized mice.

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Fig4. In vitro T cell activation with heterozygous or homozygous CD3E humanized mice.

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Fig5. Cytokine analysis of anti-human CD3E antibody treated hCD3E mice. 

The data is provided by Crownbio.