hCD40/h4-1BB(2)

Background : C57BL/6Smoc

Catalog : NM-HU-200256

Strain Name : C57BL/6Smoc-Cd40em1(hCD40)Tnfrsf9tm2(TNFRSF9)Smoc

Gene Summary

Gene Name

Model Description

hCD40(NM-HU-00076)was crossed with h4-1BB(NM-HU-190077)to generate hCD40/h4-1BB(2) mice.

Validation Data

4-1BB&CD40-1.png

4-1BB&CD40-2.png

Fig1. In vivo validation of double humanized CD40&4-1BB mice. Double humanized mice were inoculated with B16F10 cells, and randomly assigned to different groups (n=6) when the tumor grew to a volume of 80 mm3. A combinatorial treatment of anti-CD40 and anti-4-1BB inhibited tumor growth (top) without affecting the animal body weight (Bottom).

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