hFCGRT(NMG)

Background : NOD

Catalog : NM-NSG-020

Strain Name :

NOD-PrkdcscidIl2rgem1Fcgrtem2(FCGRT)Smoc

Gene Summary

Gene Name

Model Description

The background of this strain is NMG, and its endogenous Fcgrt gene is replaced with human FCGRT.

Validation Data

image.png

Fig.1 Detection of FCRN expression in kidney by RT-PCR. 

Wild type: only one band at 181 bp with primers F1/R1(mFcgrt);

Heterozygous: one band at 181 bp with primers F1/R1(mFcgrt) and one band at 310 bp with primers F2/R2(hFCGRT). 

Abbr. M, DNA marker; HE, heterozygous; WT, wild type.

image.png

Fig.2 Detection of human FCRN expression in hFCRN (NMG) mice by WB. 

Abbr. M, marker; WT1, wild type, NOD-Scid; WT2, wild type, NMG; HE, heterozygous; PC, positive control, hFCRN (NM-HU-190070).


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