Strain Model Specification

hIL10

Strain Name C57BL/6Smoc-Il10tm4(hIL10)/Smoc
Catalog Number NM-HU-2000063
Genetic Background C57BL/6Smoc
Gene Symbol Il10
Synonyms CSIF, Il-10
NCBI ID 16153 ↗
MGI ID 96537 ↗
Ensembl ID ENSMUSG00000016529 ↗
Strain State Embryo cryopreservation
Research Application Cytokine humanization model；drug screening

Validation Data

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Fig1. Detection of IL10 expression in bladder by RT-PCR. 

Wild type: only one band at 362 bp with primers F1/R1(mIl10);

Homozygous: only one band at 196 bp with primers F2/R2(hIL10).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

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Fig2. Detection of human and mouse IL10 expression in serum by ELISA (n=2). 

Abbr. HO, homozygous; WT, wild type.

Note. hIL10 and C57BL/6 mice were i.p. injected with LPS for 2h.