Strain Model Specification

hIL11/hIL11RA

Strain Name C57BL/6Smoc-Il11tm1(hIL11)Il11ra1tm1(hIL11RA)Smoc
Catalog Number NM-HU-210372
Genetic Background C57BL/6Smoc
Synonyms IL-11, NR1, GP130, Il11ra, Il-11ra, Il11ra2, AI314697
NCBI ID 16156, 16157 ↗
MGI ID 107613, 107426 ↗
Ensembl ID ENSMUSG00000004371, ENSMUSG00000073889 ↗
Strain State Embryo cryopreservation
Research Application inmmue therapy;drug screening

Validation Data

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Fig.1 Detection of IL11 expression in testis,stomach and lung by RT-PCR in hIL11/hIL11RA dKI mice. 

Wild type: only one band at 171 bp with primers F1/R1(mIl11);

Homozygous: only one band at 162 bp with primers F2/R2(hIL11). 

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

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Fig.2 Detection of IL11RA expression in testis, stomach and lung by RT-PCR in hIL11/hIL11RA dKI mice.  

Wild type: only one band at 289 bp with primers F1/R1(mIl11ra);

Homozygous: only one band at 247 bp with primers F2/R2(hIL11RA).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

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Fig.3 Detection of hIL11 expression in lung homogenate by ELISA in hIL11/hIL11RA dKI mice. 

Abbr. HO, homozygous; WT, wild type. 

Note. hIL11/hIL11RA and C57BL/6 mice were injected with LPS.

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Fig.4 Detection of human IL11RA expression in hIL11/hIL11RA dKI mice by WB. 

Abbr. HO, homozygous; WT, wild type.

Note. The IL11RA Antibody cross-reacted with mouse and humanized IL11RA. 

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Fig.5 Detection of hIL11RA expression in Kidney in C57BL/6 and HO/HO hIL11/hIL11RA knockin mice by IHC. 

Abbr. HO/HO, homozygous; WT, wild type. 

Note. The IL11RA Antibody cross-reacted with mouse and humanized IL11RA.