Il-2;CD25, Il2r, Ly-43;gc, p64, [g]c, CD132, gamma©;p70, CD122, IL15Rbeta, Il-2Rbeta, IL-15Rbeta, Il-2/15Rbeta
ENSMUSG00000027720 ENSMUSG00000026770 ENSMUSG00000031304 ENSMUSG00000068227
胚胎冻存
Fig1. Detection of hIL-2 expression by ELISA in the hIL-2 knockin mice (Wild type and heterozygous hIL-2 KI mice were administrated with concanavalin).
Fig2. Intracellular staining of IL-2 by FACS post stimulation with anti-mCD3/anti-mCD28 (In collaboration with CrownBio).
Fig3. IL-2RA humanized mouse expresses hlL-2RA (hCD25) on naïve Treg in blood (In collaboration with CrownBio).
Fig4. hlL-2RA is highly expressed on activated Tregs in spleen in the IL-2RA huamnzied mouse (In collaboration with CrownBio).
Fig5. hlL-2RA is highly expressed on activated NK cells in spleen in the IL-2RA humanized mouse (In collaboration with CrownBio).
Fig6. Immunotype in hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice.
Fig7. Immunotype in hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice in Blood.
Fig8. Immunotype in hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice in Spleen.
Fig9. Detection of Signaling integrity in hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice.
Note. Splenocytes of C57BL/6 mice were treated with anti-mCD3 and mIL-2(10 ng/ml) for 72h. Splenocytes of hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice were treated with anti-mCD3 and hIL-2(10 ng/ml) for 72h.
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