hIL2/hIL2RA(BALB/c)

Background : BALB/cAnSmoc

Catalog : NM-HU-220018

Strain Name :

BALB/cAnSmoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)/Smoc

Gene Summary

Gene Name

Model Description

The endogenous mouse Il2 and Il2ra gene was replaced respectively by human IL2 and IL2RA gene.

Validation Data

image.png

Fig1. Detection of IL2 expression in splenocyte by RT-PCR. 

Wild type: only one band at 288 bp with primers F1/R1(mIl2);

Homozygous: only one band at 388 bp with primers F2/R2(hIL2);

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig2. Detection of IL2RA expression in splenocyte by RT-PCR. 

Wild type: only one band at 350 bp with primers F1/R1(mIl2ra);

Homozygous: only one band at 318 bp with primers F2/R2(hIL2RA);

Abbr. M, DNA marker; HO, homozygous;WT, wild type.


image.png

Fig3. Detection of hIL2RA expression on splenocyte-derived T cells in hIL2/hIL2RA dKI mice.


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