Strain Model Specification

hIL2RB

Strain Name C57BL/6Smoc-Il2rbtm1(hIL2RB)/Smoc
Catalog Number NM-HU-2000055
Genetic Background C57BL/6Smoc
Gene Symbol Il2rb
Synonyms p70, CD122, IL15Rbeta, Il-2Rbeta, IL-15Rbeta, Il-2/15Rbeta
NCBI ID 16185 ↗
MGI ID 96550 ↗
Ensembl ID ENSMUSG00000068227 ↗
Strain State Embryo cryopreservation
Research Application Cytokine humanization model；drug screening

Validation Data

NM-HU-2000055 hIL2RB.png

Fig1. Analysis of IL2RB gene expression in the liver by RT-PCR.

Mouse Il2rb mRNA was detectable by P1/2(511bp), human IL2RB mRNA was detectable by P1/3(513bp), 

M:100bp Plus DNA ladder from Transgen (BM311). The heterozygous KI mouse expresses both human IL2RB and mouse Il2rb in the liver.