Strain Model Specification

hIL33

Strain Name C57BL/6Smoc-Il33tm2(hIL33)/Smoc
Catalog Number NM-HU-2000069
Genetic Background C57BL/6Smoc
Gene Symbol Il33
Synonyms Il-33, Il1f11, NF-HEV, 9230117N10Rik
NCBI ID 77125 ↗
MGI ID 1924375 ↗
Ensembl ID ENSMUSG00000024810 ↗
Strain State Embryo cryopreservation
Research Application Cytokine humanization model；drug screening

Validation Data

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Fig1. Detection of IL33 expression in lung by RT-PCR. Wild type: only one band at 287 bp with primers F1/R1(mIl33);Homozygous: only one band at 311 bp with primers F2/R2(hIL33); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig 2. Detection of hIL33 expression in lung homogenate by ELISA. Abbr. HO, homozygous; HE, heterozygous; WT, wild type.Note. hIL33 and C57BL/6 mice were i.p. injected with LPS(10mg/kg) for 4h.

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Fig 3. Detection of mIL33 expression in lung homogenate by ELISA. Abbr. HO, homozygous; HE, heterozygous; WT, wild type. Note. hIL33 and C57BL/6 mice were i.p. injected with LPS(10mg/kg) for 4h.