Strain Model Specification

hSIGLEC8(2)

Strain Name C57BL/6Smoc-Siglecftm1(hSIGLEC8)Smoc
Catalog Number NM-HU-210033
Genetic Background C57BL/6Smoc
Gene Symbol Siglecf
Synonyms Siglec5, mSiglec-F
NCBI ID 233186, ↗
MGI ID 2681107, ↗
Ensembl ID ENSMUSG00000039013, ↗
Strain State Embryo cryopreservation
Research Application inmmue therapy；drug screening

Validation Data

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Fig1. Strain specific SIGLEC8 expression analysis in homozygouse hSIGLEC8 mice by flow cytometry. Spleen derived eosinophils were collected and analyzed by flow cytometry with species-specific anti-hSIGLEC8 and anti-mSIGLEC-F antibody. hSIGLEC8 was detectable in hSIGLEC8 mice but not in WT mice, mSIGLEC-F was detectable in WT mice but not in hSIGLEC8 mice.

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Fig2. Strain specific SIGLEC8 expression analysis in homozygouse hSIGLEC8 mice by flow cytometry. Eosinophils of PBMC were collected from WT and homozygouse hSIGLEC8 mice, and analyzed by flow cytometry with species-specific anti-hSIGLEC8 and anti-mSIGLEC-F antibody. hSIGLEC8 was detectable in a small proportion of eosinophils in hSIGLEC8 mice, and the mSIGLEC-F was not expressed.