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hSIRPA(2)/hCD47

Background : C57BL/6Smoc

Catalog : NM-HU-2000111

Strain Name : C57BL/6Smoc-Sirpa^tm2(hSIRPA)Cd47^{em1(hCD47)/Smoc}

Gene Summary

Gene Name

Synonyms :
Bit, P84, SIRP, SHP-1, CD172a, Ptpns1, SHPS-1, AI835480, IAP, Itgp
NCBI ID :
19261 16423
MGI ID :
108563 96617
Ensembl ID :
ENSMUSG00000037902 ENSMUSG00000055447
Strain State :
活体

Model Description

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Validation Data

Fig 1. Detection of m&hCD47 expression on T, B, NK cells in HO hSIRPA(2)/hCD47 mice.

Fig 2. Detection of m&hCD47 expression on erythrocytes and platelets in HO hSIRPA(2)/hCD47 mice.

Fig 3. Detection of m&hCD47 expression in PB sample in HO hSIRPA(2)/hCD47 mice.

Fig 4. Detection of m&hCD47 expression in spleen sample in HO hSIRPA(2)/hCD47 mice.

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