hTARDBP

Background : C57BL/6Smoc

Catalog : NM-HU-230026

Strain Name : C57BL/6Smoc-Tardbptm(hTARDBP)Smoc

Gene Summary

Gene Name

Model Description

The endogenous mouse Tardbp gene was replaced by human TARDBP gene.

Validation Data

image.png

Fig.1 Detection of TARDBP expression in bladder by RT-PCR. 

Wild type: only one band at 247 bp with primers F1/R1(mTardbp);

Heterozygous: one band at 247 bp with primers F1/R1(mTardbp) and one band at 296 bp with primers F2/R2(hTARDBP). 

Abbr. M, DNA marker;  HE, heterozygous; WT, wild type.

image.png

Fig.2 Detection of human TARDBP expression in brain in hTARDBP knockin mice by WB. 

Abbr. HE,heterozygous; WT, wild type; M, marker.

Note: The anti-human TARDBP antibody cross-reacted with mouse TARDBP and humanized TARDBP.

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