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Home / Humanized Models / Immune Checkpoints / hTIGIT(3)

hTIGIT(3)

Background : C57BL/6Smoc

Catalog : NM-HU-200244

Strain Name : C57BL/6Smoc-Tigittm3(hTIGIT)Smoc

Gene Summary

Gene Name

Model Description

The endogenous mouse Tigit gene was replaced by human TIGIT gene. While hTIGIT(Stock No.NM-HU-00053) mice function similarly to hTIGIT（3） mice ,for more detailed information please contact our technical advisor.

Validation Data

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Fig1. Strain specific hTIGIT expression analysis in homozygouse hTIGIT mice by flow cytometry. T cells of PBMC were collected from WT and homozygouse hTIGIT mice, and analyzed by flow cytometry with species-specific anti-hTIGIT antibody. hTIGIT was expressed in T cells of homozygouse hTIGIT mice.

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Fig2. Strain specific hTIGIT expression analysis in homozygouse hTIGIT mice by flow cytometry. Spleen derived T cells were collected from WT and homozygouse hTIGIT mice, and analyzed by flow cytometry with species-specific anti-hTIGIT antibody. hTIGIT was detectable in a subset of T cells in homozygouse hTIGIT mice.

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