Cart
Humanized Models Immune-Related Mice Toolbox of Mice Genetically Edited Rats Cell lines Other ProductsSupporting Services
Tumor Targets
Immune Checkpoints
Complements
Cytokines
Cytokine Receptors
Metabolic Targets
Viral Infection Receptors
Other Targets
Humanized Models
Immunodeficient
Humanized Drug Targets
Cytokine Reporters
Inducible Cell Ablation
Cell-specific Reporter
Immune-Related Mice
Fluorescent & Other Reporters
Reporters
Find Cre
Tet-regulated
CRISPR/Cas knockins
Toolbox of Mice
Reporters
Cre-drivers
Immunodeficient
Humanized Drug Targets
Diseases
Genetically Edited Rats
Reporter-labeled
Primary Cell Lines
Wild-Type
Humanized Drug Targets
Others
Cell lines
Home / Ighm/Ighd-KO

Ighm/Ighd-KO

Background : C57BL/6Smoc

Catalog : NM-KO-200610

Strain Name :

C57BL/6Smoc-Ighmem1Ighdem1Smoc

Gene Summary

Gene Name

Model Description

Exon 1-6 of Ighm and exon 1-5 of Ighd gene was deleted to generate Ighm and Ighd knockout mice. Homozygous mutant mice lack mature B cells. It may be useful as a model for B cell immunodeficiency found in humans.

Validation Data

image.png

Fig1. Confirmation of Ighm knockout and B cell development in blood in Ighm/Ighd-KO mice by FACS.

image.png

Fig2. T cell and NK cell lineages development in blood in Ighm/Ighd-KO mice by FACS.

image.png

Fig3. In vivo anti-tumor efficacy in Ighm/Ighd-KO mice bearing MC38 syngeneic tumors.

image.png

Fig4. The impact of B cell depeltion on the anti-tumor efficacy in Ighm/Ighd-KO mice bearing mPA6115 tumors (GEMM-derived homograft).

Order Form

Please fill in the order form and we will contact you within 2 working days.

  • h4-1BB(2) NM-HU-190077 1

    Email Back to top