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Home / Ighm-KO

Ighm-KO

Background : C57BL/6Smoc

Catalog : NM-KO-18024

Strain Name : C57BL/6Smoc-Ighmem1Smoc

Gene Summary

Gene Name
  • Synonyms :

    Igm, muH, Igh6, Igh-6, Igh-M, AI326478

  • NCBI ID :

    16019

  • MGI ID :

    96448

  • Ensembl ID :

    ENSMUSG00000076617

  • Strain State :

    Embryo cryopreservation

Model Description

Exon1-6 of Ighm gene were deleted to generate Ighm knockout mice.

Validation Data

Generation strategy

图片1.png

Fig.1 Schematic diagram for the Ighm-KO mice generation strategy.

Ighm mRNA expression

图片2.png

Fig.2 Expression of Ighm mRNA in the blood and spleen tissue of WT and KO mouse strains. The result shows that Ighm was not detected in blood and spleen of Ighm-KO homozygous mice.

FACS validation of IgM knockout

Ighm knockout mouse model_05.png

Fig.3 t. FACS analysis of CD45+ cells from WT and Ighm-KO mice. The result shows that Ighm was not detected in splenocytes ,lymphocytes and bone morrow cells of  Ighm-KO mice.

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