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Il17a-Cre

Background : C57BL/6Smoc

Catalog : NM-KI-200137

Strain Name : C57BL/6Smoc-Il17a^{em1(iCre-polyA(SV40))Smoc}

Gene Summary

Gene Name

Synonyms :
Il17, Ctla8, IL-17, Ctla-8, IL-17A
NCBI ID :
16171
MGI ID :
107364
Ensembl ID :
ENSMUSG00000025929
Strain State :
活体

Model Description

A iCre-polyA expression cassette was knocked into the Il17a gene start codon site. This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying autoimmune inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis.

Validation Data

Fig 1. Cre mediated recombination in lung of Il17aCre/+;Rosa26tdTomato/+ mouse.

Fig 2. Cre mediated recombination in mesenteric lymph nodes of Il17aCre/+;Rosa26tdTomato/+ mouse.

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