Strain Model Specification

Krt5-IRES-CreERT2

Strain Name C57BL/6Smoc-Krt5em1(IRES-CreERT2)Smoc
Catalog Number NM-KI-200168
Genetic Background C57BL/6Smoc
Gene Symbol Krt5
Synonyms K5, CK5, Tfip8, Krt2-5, AW146334, 3300001P10Rik
NCBI ID 110308, , , , , ↗
MGI ID 96702, , , , , ↗
Ensembl ID ENSMUSG00000061527, , , , , ↗
Strain State Sperm cryopreservation
Research Application Cre recombinase tool

Validation Data

Krt5-IRES-CreERT2-1 - 副本.png

Fig. 1 Detection of tdTomato (red) in the epidermis and hair follicle of Krt5CreERT2/+; Rosa26tdTomato/+  mouse. CreERT2-mediated recombination in the epidermis and hair follicle of Krt5CreERT2/+; Rosa26tdTomato/+ mouse. Some leakiness were detected in the epidermis and hair follicle prior to tamoxifen exposure.

Krt5-IRES-CreERT2-2 - 副本.png

Fig. 2 Detection of tdTomato (red) in various tissues of Krt5CreERT2/+; Rosa26tdTomato/+ mice. 

CreERT2-mediated recombination in the brown fat and submandibular gland can be induced by tamoxifen. Some leakiness were detected in the skin，eyes and testis prior to tamoxifen exposure.