Strain Model Specification

Lgr5-2A-DreERT2

Strain Name C57BL/6Smoc-Lgr5em1(2A-DreERT2)Smoc
Catalog Number NM-KI-200178
Genetic Background C57BL/6Smoc
Gene Symbol Lgr5
Synonyms FEX, Gpr49
NCBI ID 14160 ↗
MGI ID 1341817 ↗
Ensembl ID ENSMUSG00000020140 ↗
Strain State Sperm cryopreservation
Research Application Dre recombinase tool

Validation Data

image.png

Fig1. Dre mediated recombination in liver of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse.

Hepatocyte expressing tdTomato(red) after tamoxifen induction of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse. (see the reference). 

image.png

Fig2. Dre mediated recombination in colon of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse.

Lgr5-2A-DreERT2 43T,46.jpg

Fig3. Detection of tdTomato(red) in various tissues of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse. 

Tissues expressing tdTomato after tamoxifen induction included the large intestine, small intestine, liver, stomach, and skin. In contrast, no significant fluorescent expression was observed in the brain, spinal cord, esophagus, muscle, vagina, or reproductive system of the mice following tamoxifen induction. (38-days old, female) (For more detailed information please contact our technical advisor.)