Lrat-2A-Cre

Background : C57BL/6Smoc

Catalog : NM-KI-190097

Strain Name : C57BL/6Smoc-Lratem1(2A-Cre)Smoc

Gene Summary

Gene Name

Model Description

A 2A-Cre expression cassette was knocked into the Lrat gene stop codon site.

Validation Data

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Fig1. Expression Pattern of tdTomato in LratCre/+ ; Rosa26tdTomato/+ mice.

Cre mediated recombination in  liver nonparenchymal cells of LratCre/+ ; Rosa26tdTomato/+ mice. This strain represents an effective tool for generating liver nonparenchymal cells specific targeted mutants.

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Fig2. Validation of  tdTomato  expression  by fluorescence assay.

The  liver nonparenchymal cells of Lrat-Cre mice were detected by fluorescence.

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Fig. 3 Detection of tdTomato(red) in various tissues of LratCre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination can be detected in some cells of the heart, liver, lung, stomach, uterus, colon, intestine, muscle and spleen. Tdtomato can not be detected in the retina, brown fat, submandibular gland or thymus. (For more detailed information please contact our technical advisor.)


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