MC38-hCD47/hPD-L1

Background : MC38

Catalog : NM-S13-TM07

Strain Name :

MC38-Cd274em1(hPDL1)Cd47em1(hCD47)/Smoc

Gene Summary

Gene Name

Model Description

The endogenous mouse Cd274(also known as PD-l1)  and Cd47 gene was replaced by human PDL1 and CD47 gene.

Validation Data

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Figure 1. hCD47/hPDL1 expression in wild-type MC38 and MC38-hCD47/hPDL1 cell lines.

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Figure 2. Tumor growth curve of MC38-hCD47/hPDL1 syngeneic model (n=4).

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Figure 3. The expression of hCD47/hPDL1 in humanized modified tumors by FACS.

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Figure 4. Antitumor activity of Bispecific-antibody in two different treatment group (n=6).

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