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MHCII/B2m-KO(NMG)

Background : NOD.Cg

Catalog : NM-NSG-014

Strain Name :

NOD.Cg-Prkdc^scidIl2rg^em1SmocH2-Ab1^em1SmocH2-Aa^em1SmocH2-Eb1^em1SmocH2-Eb2^em1SmocH2-Ea-ps^em1SmocB2m^em1Smoc

Gene Summary

Gene Name

Synonyms :
Abeta, A beta, H-2Ab, H2-Ab, Ia2, Ia-2, IAb, I-Ab, I-Abeta, Rmcs1, Aalpha, A alpha, H-2Aa, Ia1, Ia-1, I-Aalpha, H-2Eb, Ia4, Ia-4, A130038H09Rik, H-2Eb2, Ia5, Ia-5, H-2Ea, Ia3, Ia-3, I-Ealpha, beta2-m, beta 2 microglobulin, Ly-m11
NCBI ID :
14961 14960 14969 381091 100504404 12010
MGI ID :
103070 95895 95901 95902 95900 88127
Ensembl ID :
ENSMUSG00000073421 ENSMUSG00000036594 ENSMUSG00000060586 ENSMUSG00000067341 ENSMUSG00000036322 ENSMUSG00000060802
Pubmed :
Array
Strain State :
活体

Model Description

<p style="text-align: justify;">All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.

Validation Data

Fig1. Detection of MHCII and B2m expression in spleen in MHCII/B2M-dKO (NMG) mice by RT-PCR.

Fig2. Expression characterization of mouse MHC I and MHC II in MHCII/B2M-dKO (NMG) mice.

Fig3. Hematology of MHCII/B2M-dKO (NMG) mice.

Fig4. Blood biochemistry of MHCII/B2M-dKO (NMG) mice.

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