NVG-hIL15

Background : NOD.Cg

Catalog : GM-NVG-210001

Strain Name :

NOD.Cg-PrkdcscidIl2rgem1SmocIl15em1(hIL15)Smoc

Gene Summary

Gene Name

Model Description

The endogenous mice Il15 gene was replaced by human IL15 gene.

Validation Data

Human IL15 expression analysis

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Fig 1. Human IL15 expression analysis in homozygous NVG-hIL15 mice by ELISA. 

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Fig 2. Humanized immune reconstitution levels and body weight growth curves in huPBMC-NVG-hIL15 mice.

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Fig 3. Humanized immune reconstitution levels and body weight growth curves in huPBNK-NVG-hIL15 mice.

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Fig 4. Efficacy evaluation of CD20-targeting antibody using Raji huPBNK model.

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Fig 5. Functional protein detection in NK cells in the presence of anti-hCD20 antibody drug using Raji huPBNK model.

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Fig 6. ADCC efficacy research in vitro using huPBNK model.

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Fig 7. Body weight growth curves in γδT-NVG-hIL15 mice.

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Fig 8. Survial rates in γδT-NVG-hIL15 mice.

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Fig 9. Humanized immune reconstitution levels in γδT-NVG-hIL15 mice.


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