Pax7-IRES-CreERT2

Background : C57BL/6Smoc

Catalog : NM-KI-200099

Strain Name : C57BL/6Smoc-Pax7em1(IRES-Cre-ERT2)Smoc

Gene Summary

Gene Name

Model Description

A IRES-Cre-ERT2 expression cassette was knocked into the Pax7 gene stop codon site. Pax7 is expressed in myogenic progenitor cells. Pax7 is essential for the myogenic potential, survival, and proliferation of myogenic progenitors. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Pax7 after tamoxifen treatment.

Validation Data

image.png

Fig. 1 CreERT2-mediated recombination in the muscle of Pax7CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the muscle satellite cells of Pax7CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. Some leakiness were detected prior to tamoxifen exposure.

image.png

Fig. 2 Detection of tdTomato(red) in various tissues of Pax7CreERT2/+; Rosa26tdTomato/+ mice. Tdtomato can not be detected in the brain, colon, eye, heart, intestine, kidney, lung, liver, pancreas, stomach, spleen, skin, salivary gland, testis or epididymis. (For more detailed information please contact our technical advisor.)


Related Strains

Product
Product Catalog
Background
NM-KI-200042
C57BL/6Smoc
Inquire
NM-KI-00047
C57BL/6Smoc
Inquire
NM-KI-200148
C57BL/6Smoc
Inquire
NM-TG-220234
C57BL/6Smoc
Inquire
NM-KI-00133
C57BL/6Smoc
Inquire
NM-KI-240477
C57BL/6Smoc
Inquire
NM-KI-240492
C57BL/6Smoc
Inquire
NM-KI-240469
C57BL/6Smoc
Inquire
NM-KI-240468
C57BL/6Smoc
Inquire
NM-KI-240472
C57BL/6Smoc
Inquire
Email Back to top