Strain Model Specification

Slc17a6-IRES-Cre

Strain Name C57BL/6Smoc-Slc17a6em1(IRES-iCre)Smoc
Catalog Number NM-KI-200087
Genetic Background C57BL/6Smoc
Gene Symbol Slc17a6
Synonyms DNPI, VGLUT2, 2900073D12Rik
NCBI ID 140919 ↗
MGI ID 2156052 ↗
Ensembl ID ENSMUSG00000030500 ↗
Strain State Sperm cryopreservation
Research Application Cre recombinase tool; The glutamate transporter 2 gene (Vglut2/Slc17a6) is expressed in multiple brain regions. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.

Validation Data

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Fig. 1 Cre-mediated recombination in the brain of Slc17a6Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the cortex, hippocampus and thalamus derived from Slc17a6Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the retina of Slc17a6Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal ganglion cell layer derived from Slc17a6Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of Slc17a6Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the cortex, hippocampus, striatum and thalamus. TdTomato can also be detected in individual cells of the retinal ganglion cell layer and extranet layer, pituitary gland, heart, kidney, testis, epididymis, brown fat, thymus, spleen, stomach, skeletal muscle, intestine, colon, salivary gland and pancreas islet. Tdtomato expression can not be observed in the lung, liver or skin. (For more detailed information please contact our technical advisor.)