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Home / Toolbox of Mice / Find Cre / Zbtb46-2A-CreERT2

Zbtb46-2A-CreERT2

Background : C57BL/6Smoc

Catalog : NM-KI-18021

Strain Name :

C57BL/6Smoc-Zbtb46em1(2A-CreERT2-WPRE-pA)Smoc

Gene Summary

Gene Name

Model Description

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Zbtb46 gene via homologous recombination to establish a tamoxifen inducible Zbtb46-CreERT2 tool stain. This strain can be used to knockout target gene in Zbtb46+ cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Validation Data

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Fig 1. Cre-mediated recombination in spleen of Zbtb46CreERT2/+; Rosa26tdTomato/+ mice.

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Fig 2. Detection of tdTomato (red) in various tissues of Zbtb46CreERT2/+; Rosa26tdTomato/+. Expression tissues include: liver, salivary gland, pituitary gland, adrenal gland, kidney, pancreas, spleen, testis, thymus. A few cells expressed in cerebellum, spinal cord, heart, brown fat, small intestine, colon, muscle, skin. (6.5-8 weeks old, male) (For more detailed information please contact our technical advisor.) 

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